Linda K. Bockenstedt, MD is the Harold W. Jockers Professor of Medicine in the Department of Medicine, Section of Rheumatology, Allergy & Immunology at Yale School of Medicine. Her research program is devoted toward understanding the pathogenesis of Lyme disease and other Ixodes tick-borne infections in mouse models and humans. Her laboratory pioneered the use of two-photon intravital microscopy to study Lyme borreliosis in living mice and identified persistence of sterile inflammatory remnants of the Lyme bacteria in joint entheses after antibiotics. Her most recent work employs advanced systems (omics) technologies to define the initial host response to tick-borne disease in humans that may set the stage for diverse outcomes.