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An AP-3-dependent pathway directs phagosome fusion with Rab8 and Rab11 vesicles involved in TLR2 signaling

by MAO | Oct 27, 2025 | Publications

Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s

by MAO | Oct 27, 2025 | Publications

The PD-1/PD-L1 pathway is induced during Borrelia burgdorferi infection and inhibits T cell joint infiltration without compromising bacterial clearance

by MAO | Oct 27, 2025 | Publications

Antiphospholipid autoantibodies in Lyme disease arise after scavenging of host phospholipids by Borrelia burgdorferi

by MAO | Oct 27, 2025 | Publications

Lipoproteome screening of the Lyme disease agent identifies inhibitors of antibody-mediated complement killing

by MAO | Oct 27, 2025 | Publications

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The Tufts University Lyme Disease Initiative is a group of clinicians and scientists committed to working together to end Lyme disease as a threat to human health.  Taking a multi-pronged approach and partnering with researchers at other universities, in government and in industry, we are exploring unique strategies to meet our goal by the year 2030.  Visit our research pages to learn about our approaches to Lyme disease.

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Genetically engineered mice could take the bite out of Lyme disease on Nantucket, scientists say

CBS 60 Minutes:  MIT professor Kevin Estvelt and Tufts Lyme researcher Sam Telford discuss a new approach to...

New Lyme diagnostic could pinpoint disease earlier

Boston Globe: With the tick-borne illness making its annual resurgence in the region, researchers from Tufts...

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