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Publications

Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans

by Linden Hu | Jan 21, 2026 | Publications

Science Translational Medicine March 2025. Ixodes scapularis is a primary vector of tick-borne pathogens in North Americ…

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Hygromycin A Treatment of Borrelia burgdorferi-Infected Peromyscus leucopus Suggests Potential as a Reservoir-Targeted Antibiotic

by Linden Hu | Jan 20, 2026 | Publications

Journal of Infectious Diseases, 2026. Lyme disease spirochetes are maintained in natural reservoirs before spilling ove…

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Increasing Risk for Tick-Borne Disease: What Should Clinicians Know?

by MAO | Oct 27, 2025 | Publications

Many of the diverse tick-borne diseases (TBD) in the US appear to be increasing in incidence, leading to concern that fa…

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Powassan virus persistence after acute infection

by MAO | Oct 27, 2025 | Publications

Survivors of Powassan encephalitis often have persistent neurological disease. A new mouse model replicates some…

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Comparative reservoir competence of Peromyscus leucopus, C57BL/6J, and C3H/HeN for Borrelia burgdorferi B31

by MAO | Oct 27, 2025 | Publications

Although laboratory strains of Mus musculus mice have successfully been leveraged to model acute human Lyme disease,…

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Borrelia burgdorferi initiates early transcriptional re-programming in macrophages that supports long-term suppression of inflammation

by MAO | Oct 27, 2025 | Publications

Borrelia burgdorferi (Bb), the causative agent of Lyme disease, establishes a long-term infection and leads to disease…

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The Tufts University Lyme Disease Initiative is a group of clinicians and scientists committed to working together to end Lyme disease as a threat to human health.  Taking a multi-pronged approach and partnering with researchers at other universities, in government and in industry, we are exploring unique strategies to meet our goal by the year 2030.  Visit our research pages to learn about our approaches to Lyme disease.

Recent Posts

Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis

Microbial genetic variation impacts host eco-immunological strategies and microparasite fitness in Lyme borreliae-reptile system

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