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Publications

The PD-1/PD-L1 pathway is induced during Borrelia burgdorferi infection and inhibits T cell joint infiltration without compromising bacterial clearance

by MAO | Oct 27, 2025 | Publications

The Lyme disease bacterial pathogen, Borrelia burgdorferi, establishes a long-term infection inside its mammalian…

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Antiphospholipid autoantibodies in Lyme disease arise after scavenging of host phospholipids by Borrelia burgdorferi

by MAO | Oct 27, 2025 | Publications

A close association with its vertebrate and tick hosts allows Borrelia burgdorferi, the bacterium responsible for Lyme…

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Lipoproteome screening of the Lyme disease agent identifies inhibitors of antibody-mediated complement killing

by MAO | Oct 27, 2025 | Publications

Spirochetal pathogens encode an abundance of lipoproteins that can provide a critical interface with the host…

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Frequency and Geographic Distribution of Borrelia miyamotoi, Borrelia burgdorferi, and Babesia microti Infections in New England Residents

by MAO | Oct 27, 2025 | Publications

Borrelia miyamotoi is a relapsing fever spirochete that relatively recently has been reported to infect humans. It…

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A Selective Antibiotic for Lyme Disease

by MAO | Oct 27, 2025 | Publications

Lyme disease is on the rise. Caused by a spirochete Borreliella burgdorferi, it affects an estimated 500,000 people in…

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Lyme Carditis in Hospitalized Children and Adults, a Case Series

by MAO | Oct 27, 2025 | Publications

Ten children and 20 adults were admitted for Lyme carditis between June and October. Ninety percent were male, and 87%…

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The Tufts University Lyme Disease Initiative is a group of clinicians and scientists committed to working together to end Lyme disease as a threat to human health.  Taking a multi-pronged approach and partnering with researchers at other universities, in government and in industry, we are exploring unique strategies to meet our goal by the year 2030.  Visit our research pages to learn about our approaches to Lyme disease.

Recent Posts

Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans

Hygromycin A Treatment of Borrelia burgdorferi-Infected Peromyscus leucopus Suggests Potential as a Reservoir-Targeted Antibiotic

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