Intracellular compartmentalization of ligands, receptors and signaling molecules has been recognized as an important...
An AP-3-dependent pathway directs phagosome fusion with Rab8 and Rab11 vesicles involved in TLR2 signaling
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Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s
Proteolytic cascades comprise several important physiological systems, including a primary arm of innate immunity...
The PD-1/PD-L1 pathway is induced during Borrelia burgdorferi infection and inhibits T cell joint infiltration without compromising bacterial clearance
The Lyme disease bacterial pathogen, Borrelia burgdorferi, establishes a long-term infection inside its mammalian...
Antiphospholipid autoantibodies in Lyme disease arise after scavenging of host phospholipids by Borrelia burgdorferi
A close association with its vertebrate and tick hosts allows Borrelia burgdorferi, the bacterium responsible for Lyme...
Lipoproteome screening of the Lyme disease agent identifies inhibitors of antibody-mediated complement killing
Spirochetal pathogens encode an abundance of lipoproteins that can provide a critical interface with the host...
Frequency and Geographic Distribution of Borrelia miyamotoi, Borrelia burgdorferi, and Babesia microti Infections in New England Residents
Borrelia miyamotoi is a relapsing fever spirochete that relatively recently has been reported to infect humans. It...