People catch Lyme disease from ticks, who in turn get the bacteria from wild mice. But why don’t mice get the same disease? We think it’s something to do with differences in the immune systems of mice and people. Tanja and Urmila are immunologists studying these differences at the Tufts Lyme Disease Initiative. They tell us about what they’re doing in the lab to try to understand how our own immune system contributes to Lyme disease.